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Global

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Alpha 1 Antitrypsin Deficiency with Genotype MZ is a very common, but underdiagnosed hereditary medical condition, which effects the life's of > 35Mil persons globally     

Our Mission

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It is our missions to advance the understanding of Alpha 1 Antitrypsin Deficiency with Genotype MZ, for patients and medical professionals on a global basis.
Our findings are based on medical research papers and clinical cases out of the Alpha 1 MZ population.

Latest Publications

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Reduced liver functional capacity in a heterozygous PiMZ liver, which reduction accelerates with aging

This paper provides information and evidence that a PiMZ liver is under continues ER stress caused by the "Recruitment - Secretory Block (R-SB)" which results in a reduced functional capacity of the liver. During the course of the adult life this functional capacity is further decreased through aging, resulting in (serious) clinical issues.

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